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As Seen In
Dr. Alison Jamieson
MBBS, FRACGP, Dip Derm — 40+ Years in Cosmetic Medicine
“When introducing retinol, begin with twice-weekly application for the first 2 weeks, then increase frequency as tolerated toward nightly use. This graduated approach supports skin adaptation while maintaining barrier integrity and optimising long-term outcomes.”
Reverse Wrinkles Overnight
Experience the power of gold-standard rejuvenation without compromise.
Reduces Visible Wrinkles
Retinol works to smooth fine lines and reduce wrinkle depth by 20% in 12 weeks.
Fades Hyperpigmentation
Clinically proven to significantly improve pigmentation, helping to diminish dark spots and even out skin tone.
Rejuvenates Without Irritation
Microencapsulated retinol supports gradual delivery, helping minimise irritation while maintaining efficacy.
Stimulates New Collagen
Matrixyl® synthe'6™ peptide mimics injectable fillers, rebuilding skin from within for a firmer, plumper look.
Delivers Deep Hydration
Amazonian Cupuacu Butter absorbs 440% of its weight in water to provide intense, long-lasting moisture.
Maximises Potency & Stability
Micro-encapsulated delivery extends retinol's active life by 9 times, ensuring maximum results from every dose.
Stability vs. Sensitivity
Traditional retinols degrade and irritate. Aliangé transforms and soothes.
Micro-Encapsulated Actives.
Dual-action Vitamin A combined with protective Amazonian butters.
Micro-retinol
- Accelerates turnover
- 9x more stable
- Deeper penetration
- Minimal irritation
Advanced technology allows it to penetrate deeper while significantly reducing risk of 'retinol burn'.
Matrixyl® synthe'6®
- Collagan & Elastin architect
- Stimulates 6 major markers
- Rebuilds from within
- Firms & plumps
Clinical studies show it effectively rebuilds the skin matrix, visibly reducing wrinkle volume.
Cupuaçu Butter
- Absorbs 440% weight in water
- Restores elasticity
- Soothes during renewal
- Amazonian superfruit
Capable of holding over 400% of its weight in water to deeply moisturise and restore skin.
HA Crosspolymer
- Advanced Hyaluronic mesh
- Continuous hydration
- Locks in moisture
- Plump complexion
Forms a 'mesh' on the surface for long-lasting hydration that helps buffer active ingredients.
The Transformation Protocol
Your nightly sequence for cellular rejuvenation.
Cleanse
Begin by thoroughly cleansing with the Daily Devotion Cleanser.
Apply Serums
Apply your Aliangé Brightening Serum and allow it to fully absorb.
Target
Apply the Ultimate A to your face, neck, and décolletage. Any left over can be applied to back of hands.
Build Tolerance
Use 2x weekly to start, increasing frequency as skin adapts.
Frequently Asked Questions
Scientific answers to your Vitamin A concerns.
The Ultimate A Night Cream is Aliangé's overnight cellular renewal treatment — a rich, lipid-based cream that combines micro-encapsulated Retinol, Bakuchiol, and Matrixyl® synthe'6™ in a deeply hydrating base of Cupuaçu Butter, Shea Butter, and Avocado Oil. It is the most active product in the Aliangé range, designed to drive the skin's most intensive repair work during the overnight period when cell division peaks and regenerative processes are most active. Clinical testing showed 20% wrinkle reduction and 59% hyperpigmentation improvement.
Standard Retinol breaks down rapidly on contact with air, light, and skin enzymes, delivering a burst of activity followed by quick degradation. Micro-encapsulation wraps the Retinol molecule in a protective shell that releases it gradually over several hours. This technology delivers a 9x longer half-life compared to standard Retinol, meaning the active ingredient works continuously through the night rather than depleting within the first hour. The result is sustained cellular renewal with lower peak irritation — more effect, less sensitivity.
Matrixyl® synthe'6™ (Palmitoyl Tripeptide-38) is a peptide that signals fibroblasts to produce six key structural components of the skin's extracellular matrix: Collagen I, Collagen III, Collagen IV, Fibronectin, Hyaluronic Acid, and Laminin 5. This means the Night Cream doesn't just stimulate generic collagen production — it directs the synthesis of the specific structural proteins that maintain skin firmness, elasticity, and hydration. Combined with Retinol's cell renewal activity, this creates overnight conditions for both surface renewal and deep structural rebuilding.
The Night Cream's lipid-rich base serves two purposes. First, it provides an occlusive layer that reduces overnight transepidermal water loss, keeping the skin deeply hydrated during the 6–8 hours of sleep. Second, the specific lipids are chosen for active skin benefits:
- Cupuaçu Butter — absorbs 440% its weight in water, providing exceptional hydration capacity
- Shea Butter — rich in fatty acids and vitamins that nourish and soften the skin
- Avocado Oil — contains phytosterols that support barrier repair and reduce inflammation
- Sodium Hyaluronate Crosspolymer — creates a mesh-like hydration network that maintains moisture levels throughout the night
This rich base also slows the release of active ingredients, extending their contact time with the skin.
Follow this introduction schedule:
- Weeks 1–2: Apply twice per week (e.g., Monday and Thursday evenings)
- Weeks 3–4: Apply every other night
- Week 5 onward: Apply nightly
If you experience dryness or mild flaking during the introduction period, this is normal — it indicates the Retinol is accelerating cell turnover. Continue at your current frequency and ensure you are using the Biocinamide Serum (for barrier support) and the Daily Devotion Cleanser (to avoid additional barrier stress). If redness or irritation persists beyond 48 hours, reduce frequency. The micro-encapsulated delivery and 4:1 Bakuchiol ratio make this Night Cream more tolerable than most Retinol products, but gradual introduction is still recommended.
- Weeks 1–2: Smoother skin texture in the morning. The skin feels softer, more hydrated, and plumper upon waking due to the rich lipid base and overnight hydration.
- Weeks 2–4: Improved radiance and early brightening as accelerated cell turnover brings fresher cells to the surface. Fine lines begin to soften.
- Weeks 4–8: Visible wrinkle reduction and measurable improvement in pigmentation. The skin's overall tone becomes more even and luminous.
- Weeks 8–12: Peak clinical results — 20% wrinkle reduction and 59% hyperpigmentation improvement. Skin firmness and elasticity are visibly improved as collagen stimulation from Matrixyl® synthe'6™ reaches full effect.
No — the Ultimate A Night Cream contains Retinol, which is advised against during pregnancy and breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, discontinue use and consult your prescribing doctor. During pregnancy, you can continue using the other products in the Aliangé range (particularly the Biocinamide Serum, Jellyfish Peptide Serum, and Day Cream SPF 15) while substituting the Night Cream with the CellRevive Exosome Cream for overnight treatment.
If you are using a prescription retinoid (such as tretinoin/Retin-A), the Ultimate A Night Cream provides additional Retinol that may be excessive when combined. Consider alternating: use your prescription retinoid on some nights and the Ultimate A Night Cream on others. This allows you to benefit from the Night Cream's additional active ingredients (Bakuchiol, Matrixyl® synthe'6™, Cupuaçu Butter) without doubling up on retinoid exposure. Discuss with your prescribing doctor.
A regular night cream hydrates the skin while you sleep. The Ultimate A Night Cream transforms it. The micro-encapsulated Retinol drives sustained cell renewal all night. Bakuchiol amplifies the retinoid effect through a separate pathway. Matrixyl® synthe'6™ directs fibroblasts to build six specific structural proteins. And the lipid base of Cupuaçu, Shea, and Avocado doesn't just moisturise — it creates optimal conditions for active ingredient delivery while actively repairing the barrier. A regular night cream maintains. This cream rebuilds.
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